I'm not familiar with Strange Horticulture, so I've just had a wee look at the steam page & trailer videos for it.
I would say aye it should be possible to make games similar to Strange Horticulture & Papers, Please. They are just images/animations for the most part with values & conditions being used to control what is being displayed after all.
The type of mini-games/puzzles I saw in the trailer of Strange Horticulture would require scripting mind, but then again that's probably true for whichever game engine you might use.
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