Couple of quick questions...
1. have you assigned an animation center for each of your characters animations? This determines which part of the character sprite will move to the destination position you set when clicking the left mouse button somewhere in a scene. The typical place to set the animation center is somewhere near & inbetween the feet of your characters. The animation center ideally should be the same position for each animation associated with the character.
2. have you set the animation center for the mouse? Typically this would be set on the tip of the cursor & should be the same position for both the active & inactive cursor. The animation center of mouse cursor is what is used to draw the cursor where the mouse cursor should be on your windows/mac machine.
P.S: having incorrect animation centers means your cursors & characters etc are not being drawing in the position you want them to be drawn at, which means your character is offset from the position you have specified or the mouse cursor is offset from the position of your system cursor.